Colon and Rectum

Colorectal cancer: symptoms, diagnosis and treatment

Colorectal cancer usually begins as a polyp — a small, non-cancerous growth that turns malignant over years. That long runway is precisely why screening works here better than in almost any other cancer.

What is colorectal cancer?

Colorectal cancer is malignancy developing in the colon or rectum. It typically begins as small, non-cancerous growths called polyps, which can gradually turn into cancer over time.

What are the risk factors?

  • Age: most cases occur in people over 50.
  • Family history: increases risk significantly.
  • Lifestyle: high red and processed meat consumption, obesity, smoking and heavy alcohol use.
  • Medical conditions: inflammatory bowel disease and genetic syndromes such as Lynch syndrome or familial adenomatous polyposis.

What are the symptoms?

Early-stage colorectal cancer often has no symptoms at all, which is what makes regular screening essential.

When symptoms are present, they include:

  • Changes in bowel habit lasting weeks.
  • Rectal bleeding or blood in the stool.
  • Persistent abdominal pain or cramping.
  • Unexplained weight loss.
  • Fatigue or weakness from anaemia.

How is it diagnosed?

  • Colonoscopy: camera examination allowing polyp removal and biopsy.
  • Biopsy: tissue analysis confirming the cancer.
  • Imaging: CT, MRI or PET scans to assess extent.
  • Blood tests, including carcinoembryonic antigen (CEA).

Guidelines recommend screening beginning at age 45, or earlier where risk factors are present.

What are the treatment options?

  • Surgery: polypectomy, partial colectomy or abdominoperineal resection.
  • Chemotherapy: before or after surgery in advanced stages.
  • Radiation therapy: combined with chemotherapy for rectal cancers.
  • Targeted therapy: drugs directed at cancer cells specifically.
  • Immunotherapy: for certain genetic subtypes.

What is recovery like?

  • Hospital stays typically last 3–7 days after surgery, with full recovery taking 4–6 weeks.
  • Dietary adjustment beginning with soft or low-fibre foods is often necessary.
  • Chemotherapy or radiation involves multiple sessions, with side effects that can include fatigue and nausea.
  • Regular follow-up monitors for recurrence.

Can it be prevented?

  • Regular colonoscopy, detecting and removing polyps.
  • A diet emphasising whole grains, fruit, vegetables and lean protein.
  • Maintaining a healthy weight.
  • Regular exercise.
  • Avoiding smoking and limiting alcohol.

What is the prognosis?

Early-stage cancers have a high survival rate, with up to 90% of patients surviving five years or more after treatment.

More on the colon and rectum

Related conditions handled by the same team.

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